Chemical Induced Liver Injury: Types, Mechanisms and Biomarkers
نویسندگان
چکیده
منابع مشابه
Biomarkers for drug-induced liver injury.
Of the estimated 10,000 documented human drugs, more than 1000 have been associated with drug-induced liver injury (DILI), although causality has not always been established clearly. Numerous biomarkers for DILI have been explored, but less than ten are adopted or qualified as valid by the US FDA. The biomarkers for DILI are individual or a panel of proteins, nucleic acids or metabolites from v...
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Drug-induced liver injury (DILI) is major problem for both the drug industry and for clinicians. There are two basic categories of DILI: intrinsic and idiosyncratic. The former is the chief cause of acute liver failure in several developed countries, while the latter is the most common reason for post-marketing drug withdrawal and a major reason for failure to approve new drugs in the U.S. Alth...
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Drug-induced liver injury (DILI) is a potentially fatal adverse event with significant medical and economic impact. Many drugs, especially anti-infective, neurologic or pain-modifying substances, act as hepatotoxins. With cardiovascular toxicity, liver toxicity is one of the two leading causes for drug withdrawal from the market. The liver can be affected directly, in a predictable and dose-dep...
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Drug-induced liver injury is a frequent side effect of many drugs, constitutes a significant threat to patient health and has an enormous economic impact on health care expenditures. Numerous efforts have been made to identify reliable and predictive markers to detect the early signs of drug-induced injury to the liver, one of the most vulnerable organs in the body. These studies have, however,...
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Schwabe, Robert F., and David A. Brenner. Mechanisms of Liver Injury. I. TNF-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 290: G583– G589, 2006; doi:10.1152/ajpgi.00422.2005.—TNFactivates several intracellular pathways to regulate inflammation, cell death, and proliferation. In the liver, TNFis not only a mediator of hepatotoxicity but also c...
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ژورنال
عنوان ژورنال: Anatomical Science
سال: 2018
ISSN: 2578-1804
DOI: 10.24294/as.v1i3.903